Clinical trial for dialysis-related amyloidosis with an adsorbent column for .BETA.2-microglobulin removal.
نویسندگان
چکیده
منابع مشابه
Reduction of circulating beta2-microglobulin level for the treatment of dialysis-related amyloidosis.
Dialysis-related amyloidosis (DRA) is a common complication associated with long-term haemodialysis therapy. The elimination of beta2-microglobulin (beta2m), the major constituent of the amyloid fibrils in DRA, from circulation has been expected to bring some clinical benefit. Recently, a direct haemoperfusion method using selective beta2m absorption column to eliminate circulating beta2m has b...
متن کاملbeta(2)-Microglobulin-selective direct hemoperfusion column for the treatment of dialysis-related amyloidosis.
Lixelle is a direct hemoperfusion-type adsorption column that was developed to selectively eliminate beta2-microglobulin (beta2-m) from the circulating blood of patients with dialysis-related amyloidosis (DRA). The adsorbent in Lixelle comprises porous cellulose beads to which hydrophobic hexadecyl alkyl chain is covalently bound. One milliliter of wet Lixelle beads eliminates more than 1 mg of...
متن کاملCollagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis.
Dialysis-related amyloidosis is characterized by the deposition of insoluble fibrils of beta(2)-microglobulin (beta(2)-m) in the musculoskeletal system. Atomic force microscopy inspection of ex vivo amyloid material reveals the presence of bundles of fibrils often associated to collagen fibrils. Aggregation experiments were undertaken in vitro with the aim of reproducing the physiopathological ...
متن کاملDialysis-related amyloidosis.
end-stage failure patients which has been recognized a Amyloid arthropathy decade ago. It generally occurs after several years of The deposition of b2M amyloid clearly is associated renal replacement therapy [1,2]. However, it may be with the syndrome of chronic arthralgias and arthropaseen occasionally in patients with long-standing, severe thy in dialysis patients, although the precise pathog...
متن کاملColumn operation studies for the removal of dyes and phenols using a low cost adsorbent
Fertilizer plant waste carbon slurry has been investigated after some processing as an adsorbent for the removal of dyes and phenols using columns. The results show that the carbonaceous adsorbent prepared from carbon slurry being porous and having appreciable surface area (380 m2/g) can remove dyes both cationic (meldola blue, methylene blue, chrysoidine G, crystal violet) as well a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Japanese Society for Dialysis Therapy
سال: 1993
ISSN: 0911-5889,1884-6211
DOI: 10.4009/jsdt1985.26.1763